Table 2 Yeast endocytosis proteins, partners, domains and mammalian homologs
Yeast proteinPhysical interaction partnersKey domains, motifsHomolog, common namea
Early coat proteins
Ede1Syp1, Yap1801/2, Ent1/2EH, CC, UBAEps15
Syp1Ede1F-BAR, µHD, PRDFCHO1/2
Chc1Clc1, Yap1801/2, Ent1/2, Sla1β-propellerClathrin heavy chain
Clc1Chc1, Sla2Clathrin light chain
Pal1Ede1NPFUnknown
Apl1Apl3, Apm4, Aps2AP2 complex β2 subunit
Apl3Apl1, Apm4, Aps2AP2 complex α subunit
Apm4Apl1, Apl3, Aps2µAP2 complex μ2 subunit
Aps2Apl1, Apl3, Apm4AP2 complex σ2 subunit
Middle coat proteins
Sla2Sla1, End3, Pan1, Clc1, Act1ANTH, CC, THATCHHip1R, Hip1
Yap1801, Yap1802Pan1, Ede1, Chc1ANTH, NPF, CBMCALM, AP180
Ent1, Ent2Pan1, Ede1, Chc1, ubiquitinENTH, UIM, NPF, CBMEpsin
Late coat proteins
Sla1Pan1, End3, Sla2, Chc1, Scd5SH3, SHD1, SHD2, SR repeats, CBMCIN85
Pan1Sla1, End3, Sla2, Yap1801/2, Ent1/2, Myo3/5, Scd5EH, CC, PRD, WH2, acidicIntersectin
End3Sla1, Pan1, Scd5EH, CC
Lsb3Las17, Ldb17SH3SH3YL1a
Ysc84/Lsb4Las17, Ldb17SH3SH3YL1a
Lsb5Sla1, Las17VHS, GATGGA?
WASP/Myosin I
Las17Vrp1, Sla1, Bbc1, Syp1, Lsb1-5, Bzz1, Myo3/5, Rvs167WH1/EVH1, PRD, WH2, acidicWASP/N-WASP
Vrp1Las17, Myo3/5, Act1PRD, WH2WIP (WASP interacting protein)
Bzz1Las17, Ldb17F-BAR, SH3Syndapin
Scd5Glc7, Sla1, End3, Pan1Unknown
Myo3, Myo5Act1, Pan1, Cmd1, Pan1, Vrp1, Las17Motor, TH1, TH2, SH3, acidicType I Myosin
Bbc1Las17SH3, PRDUnknown
Ldb17Sla1, Bzz1, Lsb3, Ysc84/Lsb4, Bem1PRDDIP/WISH/SPIN90
Actinb
Act1Actin
Pfy1Srv2, Bni1, Bnr1Profilin
Arp2, Arp3, Arc15/18/19/35/40Las17, Myo3/5, Pan1, Abp1, Gmf1, Crn1ARP, β-propellerArp2/3 complex
Abp1Arp2/3, Rvs167, Aim3, Srv2, Scp1, Ark1, Prk1, Sjl2ADFH, SH3, PRD, acidicABP1
Aim3Abp1, Rvs167PRD, NPFUnknown
Srv2/CAPCof1, Pfy1, Abp1, Twf1, Aip1HFD, β-sheet, PRD, WH2Cyclase associated protein
Ark1, Prk1, Akl1Abp1Ser/Thr kinase, PRDAAK1, GAK
Cap1, Cap2Twf1Capping protein (αβ subunits)
Sac6CHFimbrin
Scp1Abp1CH, PRD, CLRCalponin/Transgelin
Abp140Unknown
Cof1Srv2, Crn1, Aip1ADFHCofilin
Twf1Cap1/2, Srv2ADFHTwinfilin
Crn1Arp2/3, Cof1β-propeller, CCCoronin
Gmf1Arp2/3ADFHGMF (glial maturation factor)
Aip1Cof1, Srv2β-propellerAip1
Scission
Rvs161Rvs167N-BARAmphiphysin
Rvs167Rvs161, Abp1, Las17N-BAR, SH3Amphiphysin/endophilin
Vps1Sla1GTPaseDynamin
Inp52/Sjl2Abp1phosphatase XYZSynaptojanin 1
Less-well-characterized proteins
Lsb1Las17SH3
Pin3/Lsb2SH3
Bsp1Unknown
Gts1Unknown
App1Unknown
Ypp1
Aim21Unknown
Swf1Palmitoyl transferase 1
  • a Any gene for which a clearly identifiable homolog is currently unknown is indicated as such, even if presently seems to be specific to fungi.

  • b Act1 is not listed as a binding partner for proteins in this subsection.