Table 1 The power comparison between BF cutoff of 106 and P-value cutoff of 10−8 under different simulation conditions
ConditionsPower
Case/controlSporadic rateaCausal haplotypesBF > 106P-value < 10−8
1000/10000.0121.001.00
40.950.95
80.720.71
0.0220.980.98
40.930.93
80.590.53
2000/20000.0121.001.00
40.980.98
80.840.83
0.0220.990.99
40.970.97
80.710.71
• The result was obtained using a single EM run so that the P-value is valid. Under all simulation conditions considered, two sets of powers are close to each other, and the BF cutoff of 106 has slightly better power than the P-value cutoff of 10−8.

• a The penetrance is assumed to be fixed at 0.10, so that a higher sporadic rate results in a lower power.