Table 3 Mutant allele frequencies in bacteriophage data from Bollback et al. (2007) and the application of the ELRT and the FIT
PassageaELRTbFIT
LineMutation010152025304050ŇEmbedded ImageŝtFId.f.P
1C206U0/100/10NA1/10NA3/1010/1010/10NANANA2.5510.119
C1549U/A0/100/10NA0/10NA6/105/109/1056.59.70.200.5910.330
G1551A0/100/10NA0/10NA1/105/101/1011.34.2−0.010.2510.422
2C206U0/100/91/91/10NA3/109/109/1019.799.20.161.5130.114
C1549U/A0/100/90/109/10NA6/910/108/10NANANA−0.1010.532
G1551A0/100/90/101/10NA2/90/102/10NANANA−0.1410.545
U466C0/102/93/910/10NA10/1010/1010/10NANANA1.2910.210
3C206U0/100/10NA1/105/104/107/1010/1012.630.30.211.6130.103
C1549U/A0/100/10NA0/105/105/103/101/10187.5405.4−0.09−1.9920.908
C3224U0/100/10NA0/100/103/107/1010/10NANANA7.0010.045
C3220U0/100/10NA0/100/103/108/1010/10NANANA2.6910.113
G1551A0/100/10NA0/100/102/107/109/1022.1652.40.192.0710.143
U466C0/100/10NA4/105/109/1010/1010/1028.239.20.332.1320.083
  • a Estimated mutant allele frequencies at different time points (passages) are shown. Data points used for the ELRT and the FIT are in boldface type (if the last of these data points was at frequency 0 or 1, it was not used for the ELRT).

  • b ML parameter values are shown. Embedded Image and ŝ maximize likelihood (9) and Ň maximizes likelihood (10) under the Gaussian approximation. Note that since all Ň are very small, the ELRT P-values cannot be obtained due to frequent absorption events in neutral Wright–Fisher simulations.