Table 4 Conservation of the dauer pathway
C. elegans proteinCelePpacPredBxylMhapBmalAsuuTspiNvit
Pheromone
 DAF-221113111x1
 DAF-61111111xx
Guanylyl cyclases
 DAF-111111x11xx
 DAF-21111x11112
 DAF-101x11x1111
TGFβ-like pathway
 DAF-11111x1122
 DAF-4131111112
 DAF-7111112111
 DAF-8313313323
 DAF-141xxxxxxxx
 DAF-3251211221
 DAF-51xxxxxxxx
Insulin-like pathway
 DAF-21122x4221
 DAF-1611a1212112
 DAF-23/AGE-11111111x1
Steroid hormone
 DAF-91121x11xx
 DAF-121111x12xx
Other effectors
 DAF-151111x1111
 DAF-19111112111
 DAF-18111111111
 DAF-288xxxxxxxx
 DAF-3611xxx41x3
 TAX-211111x1xx
 TAX-4111211111
 EGL-4121111211
  • Shown are the number of proteins from each species analyzed that cluster as orthologs with the known C. elegans protein. “x” indicates that no proteins from the proteome used clustered with the known C. elegans protein. Descriptive labels for certain pathway components known in C. elegans are given in the first column. Results are based on an orthology analysis using the available proteomes and OrthoMCL (see Supporting Information).

  • a Note that, while daf-16 was not present in the version of the proteome that we used, it is known to be present in the P. pacificus genome (Ogawa et al. 2011).