Table 4  Mean numbers (1000 replicate simulations) of escape epitope fixations at 78 days (E78) and 200 days (E200) p.i. with a CD8+ T cell response declining logistically at rate b to asymptotic minimum killing rate cmin
cminbE78E200
04.2723.41
0.22.02.2910.95
0.10.212.488.51
0.090.172.548.51
0.182.51*8.30*
0.192.448.16
0.050.062.718.81
0.072.58*8.26*
0.082.497.89
0.010.0102.718.55
0.0112.68*8.26*
0.0122.59*7.98*
0.0152.497.37
  • Asterisks indicate matches to observed numbers of fixed escape epitopes at both time points rounded to the nearest whole number: E78 = 3 and E200 = 8. Parameter values in italics indicate those used in subsequent simulations.