TABLE 1

The effect of TRP channel mutations on noxious heat avoidance

SubfamilyGene namePercentage avoiding (mean ± SD)a
TRPMLcup-599 ± 1
TRPAtrpa-196 ± 1
trpa-293 ± 3
TRPCtrp-195 ± 3
trp-2100 ± 0
TRPNtrp-498 ± 1
TRPMgon-299 ± 1
gtl-1100 ± 0
F56F11.592 ± 5
W03B1.295 ± 2
F13B12.399 ± 1
TRPPpkd-2100 ± 0
lov-197 ± 2
TRPVosm-989 ± 2*
ocr-199 ± 0
ocr-294 ± 4
ocr-395 ± 3
ocr-499 ± 9
Wild type (N2)97 ± 1
  • At least four assays conducted per genotype. One-way ANOVA F(18,135) = 1.99, P = 0.01. *P = 0.02 vs. N2 by Dunnet posthoc tests.

  • a Average fraction of animals avoiding the thermal barrier (T = 32°), normalized to respective control assays with no heat.