TABLE 1

GO terms enriched in genes with long CpG island promoters

Biological processesMolecular function
Overrepresented GO termFisher's exact test P-valueOverrepresented GO termFisher's exact test P-value
Development1.0 × 10−15Transcription factor activity1.8 × 10−16
Regulation of transcription, DNA dependent7.1 × 10−12Transcription regulation activity2.8 × 10−15
Regulation of nucleobase, nucleoside, nucleotide,  and nucleic acid metabolism1.1 × 10−11Sequence-specific DNA binding9.3 × 10−11
Regulation of transcription1.4 × 10−11DNA binding1.7 × 10−10
Transcription, DNA dependent4.4 × 10−11Transmembrane receptor activity1.0 × 10−5
Regulation of cellular metabolism1.5 × 10−10Signal transducer activity2.3 × 10−5
Transcription1.6 × 10−10G-protein–coupled receptor activity4.1 × 10−5
Regulation of cellular physiological processes2.1 × 10−10Nucleic acid binding5.3 × 10−5
Regulation of biological processes2.4 × 10−10Receptor activity9.8 × 10−5
Regulation of metabolism4.9 × 10−10Binding1.9 × 10−4