TABLE 2

QTL on chromosome 18 for activity on day 3 (2 mg/kg methamphetamine), using F2, AIL, and integrated analysis

PopulationLOD% variance2-LOD support (cM)2-LOD support (Mb)
F25.385.5116.1125.49
AIL5.062.180.871.56
Integrated10.503.740.871.56
  • A significant QTL was identified on chromosome 18 using F2, AIL, and the integrated analysis of both populations. The LG/J homozygotes showed a greater response to methamphetamine; the heterozygotes and SM/J homozygotes showed approximately similar responses, consistent with a recessive LG/J allele effect.