TABLE 4

Species differences in genes regulated by the sex determination heirarchy

GeneMolecular FunctionRegulationMel-Sim
CG10560fru (head)−0.83
CG15422fru (head)0.96
CG16898fru (head)−0.82
CG17324UDP-glycosyltransferase activityfru (head)0.64
CG18343fru (head)1.85
CG31205Serine-type endopeptidase activityfru (head)1.27
CG6129Nucleotide bindingfru (head)−0.59
CG7300fru (head)1.13
Cyp6a20Monooxygenase activityfru (head)−1.44
Cyp6d2Monooxygenase activityfru (head)0.25
GstE1Glutathione transferase activityfru (head)1.14
Obp99bOdorant bindingfru (head)−1.75
TequilaSerine-type endopeptidase activityfru (head)−1.22
TequilaSerine-type endopeptidase activityfru (head)−2.31
TequilaSerine-type endopeptidase activityfru (head)−1.81
TequilaSerine-type endopeptidase activityfru (head)−2.87
Ugt35bGlucuronosyltransferase activityfru (head)−0.53
bwEye pigment precursor transporter activityfru (head)−0.68
rgrTranscription factor activityfru (head)0.52
Cyp6a2Monooxygenase activityFru (CNS)−1.45
CG15279Neurotransmitter transporter activitytra0.49
CG16772tra0.87
CG2249Cytochrome-c oxidase activitytra1.02
CG5172tra0.82
CG9362Glutathione transferase activitytra0.58
CG9928tra0.68
GltCalcium ion bindingtra1.30
TotAtra1.67
TotCtra2.09
wupATropomyosin bindingtra0.82
CG10904tra (only)0.46
CG7356Protein-glutamine gamma-glutamyltransferase activitytra (only)0.78
CG7356Protein-glutamine gamma-glutamyltransferase activitytra (only)1.42
Iristra (only)2.13
CG16876tra, dsx0.28
Cyp6d5Monooxygenase activitytra, dsx1.04
rosttra, dsx0.77
CG4757Carboxylesterase activitytra, fru (head)2.31
  • Estimates of species differences (OEmm − OEss) in overall expression between the D. melanogaster and D. simulans lines used in the study are reported for genes with experimental demonstration of regulation by genes in the sex determination hierarchy (Goldman and Arbeitman 2007). Of 216 genes comparable between studies, 34 (including 2 with multiple probe sets) were significant at FDR < 0.2 for species differences in this study. Regulatory information given in column three is from the study of sex-specific regulation in Drosophila heads by Goldman and Arbeitman (2007). GO molecular function annotation is from FlyBase (FlyBase 2009_01, January 23) determined by manual lookup of the gene symbol.