TABLE 4

Genetic interactions between mett-10 and known meiotic entry genes

Genotype% tumorousn or reference
mett-10(oz36)a41b66
gld-1(q485)a0cFrancis et al. (1995a)
gld-1(q485); mett-10(oz36)a0c21
gld-2(q497)a2dKadyk and Kimble (1998)
gld-2(q497); mett-10(ok2204)a0102
gld-2(q497); mett-10(oz36)a100b98
gld-2(q497); glp-1(bn18) mett-10(oz36)a097
gld-2(q497); glp-1(q175) mett-10(oz36)ae044
gld-3(q730)f0Eckmann et al. (2004)
gld-3(q730); mett-10(oz36)f100d47
gld-3(q730); glp-1(q175) mett-10(oz36)ae028
  • Tumorous includes proliferation throughout the germ line, although some germ cells in various meiotic stages may be observed. All phenotypes scored by DIC at 20°.

  • a Animals with maternal mett-10 gene product (m+ z−).

  • b Late-onset tumors in which there is a significant extension of the distal proliferative zone, often filling the entire germ line.

  • c Data are from male germ lines, as gld-1(q485) hermaphrodites have proximal proliferation due to a return to mitosis (Francis et al. 1995a).

  • d Proximal proliferation.

  • e Homozygous for unc-32(e189).

  • f Animals without maternal gene product (m− z−).