TABLE 8

Genes under natural selection

CEPH indexChromosomeαFSTOMIMGene
6023−1.450.00997NoZPLD1
57012−1.420.00882YesTMEM16B
47112−1.090.0117YesPRMT8
6046−1.020.015YesEPHA7
67410−0.9810.0157YesOIT3
23416−0.960.0213NoRPL3L
6005−0.9550.013YesPDE4D
4773−0.9190.0134YesGPD1L
4337−0.9050.0136YesPRKAG2
5327−0.6940.02YesPLXNA4
49510.5230.0633YesC8B
337X0.5890.0551YesIL1RAPL1
1540.7380.0771YesSLEB3
739170.8650.0721YesRAB37
35120.9450.0766NoARMC9
2211.070.103YesLYST
26561.080.136YesPHACTR1
26X1.280.125YesEBM
  • Genes identified as under balancing (α < 0) and directional (α > 0) selection with the corresponding posterior estimate of FST are shown. Highest absolute values of α suggest a stronger effect of selection. For each gene, we present the chromosome location and the corresponding marker number in the HGDP–CEPH database. We also indicate whether the genes are present in the Online Mendelian Inheritance in Man (OMIM) database.