TABLE 3

Recovery and fertility testing of Pax6 compound heterozygotes

Phenotype class (%)a
Cross0Minor iris anomaly, 25, 50, 75, or 100Extreme microphthalmia
Pax64Neu−/+ × Pax6132-14Neu−/−21611
Pax64Neu/Pax6132-14Neu × +/+324
Pax64Neu/Pax6132-14Neu × Pax6132-14Neu−/−36
Pax67Neu−/+ × Pax6132-14Neu−/−199
Pax67Neu/Pax6132-14Neu × +/+29
Pax67Neu/Pax6132-14Neu × Pax6132-14Neu−/−10
Pax6Sey-Neu−/+ × Pax6132-14Neu−/−2145
Pax6Sey-Neu/Pax6132-14Neu × +/+111
Pax6Sey-Neu/Pax6132-14Neu × Pax6132-14Neu−/−20
Pax62Neu−/+ × Pax6132-14Neu−/−168
Pax62Neu/Pax6132-14Neu × +/+26
Pax62Neu/Pax6132-14Neu × Pax6132-14Neu−/−9
Pax63Neu−/+ × Pax6132-14Neu−/−97
  • a Phenotype classes are as in Table 1.