TABLE 2

Mosaic structure in influenza A hemagglutinin gene

Dunn–Šidák
pqcNullObserved maximumP-valueObserved maximum descentP-valueMaximummd
1979h1961s1918hH148,15970.4546a4.00 × 10−40.03
1961s1979h1918hH159,14839b7.85 × 10−430c5.22 × 10−30.05NS
1979h1961s1930sH94,218011241
1961s1979h1930sH218,94124110d9.06 × 10−3NS
1979h1961s1984hH92,220011281
1961s1979h1984hH220,92128112e8.88 × 10−40.06
  • The first three columns refer to the five influenza sequences mentioned in the Influenza A section. Here, the sequences are referred to by year and whether the sequence is human (h) or swine (s). The last two columns show the Dunn–Šidák corrected P-values given that without any knowledge about which sequences are recombinant, 60 comparisons would have to be made to test all parent–parent–child combinations. The breakpoint descriptions listed in footnotes a–e refer to a gapped alignment of length 1778 nt; 80 positions are gapped.

  • a There are 90 pairs of breakpoints that result in a maximum descent of 46 units in the diagrammed walk from these three sequences. The first breakpoint is in position 242–247, while the second one is in 953–955/971–982.

  • b The maximum height of 39 for this triple can be attained by 15 different breakpoints, at positions 952–954/970–981.

  • c There are 30 pairs of breakpoints that result in a maximum descent of 30 for this sequence triple. The first breakpoint is in position 953–955/971–982; the second breakpoint is either in position 1653 or in position 1654.

  • d There are 45 pairs of breakpoints that result in a maximum descent of 10 for this sequence triple. The first breakpoint is in position 953–955/971–982; the second breakpoint is in position 1049–1051.

  • e There are 9 pairs of breakpoints that result in a maximum descent of 12 for this sequence triple. The first breakpoint is in position 953–955; the second breakpoint is in position 1049–1051.