TABLE 6

Simulations showing the effect of population growth on the proportion of singleton polymorphisms observed in a sample of 240

Time of growthaN ratiobProportion of singletonscP (sim > obs)d
0.16610
0.13330.10.25750
0.13330.010.27260
0.13330.0010.27450
0.13330.00010.27480
0.13330.000010.27480
0.13330.0000010.27480
0.013330.10.41470
0.013330.010.51590.2315
0.013330.0010.52890.4084
0.013330.00010.53010.4204
0.013330.000010.53060.4318
0.013330.0000010.53040.4327
0.0013330.10.37500
0.0013330.010.74661
0.0013330.0010.85811
0.0013330.00010.87211
0.0013330.000010.87321
0.0013330.0000010.87341
0.0001330.10.20450
0.0001330.010.44960.0098
0.0001330.0010.85291
0.0001330.00010.96921
0.0001330.000010.98291
0.0001330.0000010.98431
  • a The time, in coalescent units before the present, when an instantaneous population-size increase occurred.

  • b The ratio of the preincrease population size to the postincrease population size.

  • c The average proportion of singletons observed across 10,000 simulated replicates.

  • d The proportion of simulated replicates that contained a greater proportion of singletons than the observed data.