TABLE 6

Simulations showing the effect of population growth on the proportion of singleton polymorphisms observed in a sample of 240

Time of growth^a	N ratio^b	Proportion of singletons^c	P (sim > obs)^d
—	—	0.1661	0
0.1333	0.1	0.2575	0
0.1333	0.01	0.2726	0
0.1333	0.001	0.2745	0
0.1333	0.0001	0.2748	0
0.1333	0.00001	0.2748	0
0.1333	0.000001	0.2748	0
0.01333	0.1	0.4147	0
0.01333	0.01	0.5159	0.2315
0.01333	0.001	0.5289	0.4084
0.01333	0.0001	0.5301	0.4204
0.01333	0.00001	0.5306	0.4318
0.01333	0.000001	0.5304	0.4327
0.001333	0.1	0.3750	0
0.001333	0.01	0.7466	1
0.001333	0.001	0.8581	1
0.001333	0.0001	0.8721	1
0.001333	0.00001	0.8732	1
0.001333	0.000001	0.8734	1
0.000133	0.1	0.2045	0
0.000133	0.01	0.4496	0.0098
0.000133	0.001	0.8529	1
0.000133	0.0001	0.9692	1
0.000133	0.00001	0.9829	1
0.000133	0.000001	0.9843	1

↵a The time, in coalescent units before the present, when an instantaneous population-size increase occurred.
↵b The ratio of the preincrease population size to the postincrease population size.
↵c The average proportion of singletons observed across 10,000 simulated replicates.
↵d The proportion of simulated replicates that contained a greater proportion of singletons than the observed data.