TABLE 8

Predominant amino acid replacement types in mitochondrial genes by intra- and interspecies comparisons

NocAla ↔ ThrIle ↔ ValIle ↔ ThrPhe ↔ LeuAsn ↔ SerMet ↔ ThrSer ↔ ThrIle ↔ LeuMet ↔ LeuOther
Human–humana4140.2730.1450.080.070.0580.0290.010.0050.0050.326
Human–chimpanzeeb1670.180.1320.0780.0420.0660.0720.042*0.0120.0120.365
Chimpanzee–orangutan4520.119*0.071*0.0820.0660.0310.0530.04*0.029*0.042*0.467
Cat–dog960.055*0.1070.0470.025*0.02*0.030.07*0.045*0.087*0.515
Pig–cow4790.054*0.090.035*0.0330.0270.050.044*0.063*0.117*0.486
  • * Difference from the human-human pattern; χ2 probability P < 0.01. Only the most frequent (>5% in at least one comparison) amino acid replacement types are reported.

  • a Proportions of specified amino acid changes as reported in the tree of 277 human sequences (Figure 1).

  • b Proportions of changes between rCRC (NC_001807.3) and P. troglodytes (D38113): orangutan (D38115); pig (AJ002189); dog (AY729880); cat (NC_001700); and cow (V00654) sequences.

  • c Total number of observed amino acid replacements.