TABLE 1

Correction and lineage substitutions in the RPL4 and NTH1/2 genes

LengthMismatch
 positionsType
 CType
 LType
 N
RPL4a,b1089 6940  0 0
NTH1,223559703130535
  • “Length” is the length of the nucleotide alignment, and in these cases is the length of the open reading frame of the gene. “Mismatch positions” is the number of positions where all four nucleotides in the alignment are not identical, e.g., an alignment of T:T:T:C or T:T:C:C, etc. “Type C” is a mismatch position of the C type, characteristic of correction, where the two cerevisae genes share the same nucleotide and the two bayanus genes share a different nucleotide (e.g., T:T:C:C). “Type L” is a mismatch position of the L type, characteristic of the gene lineage, where cerevisiae gene 1 and its bayanus homolog share the same nucleotide, while cerevisiae gene 2 and its bayanus homolog share a different nucleotide (e.g., T:C:T:C). “Type N” is a mismatch position characteristic of mutational noise, where cerevisiae gene 1 and its bayanus nonhomolog share the same nucleotide, while cerevisiae gene 2 and its bayanus nonhomolog share a different nucleotide (e.g., T:C:C:T). Positions of the type T:T:T:C (i.e., one nucleotide at odds with the other three) are mismatch positions, but are not C or L or N.