TABLE 2

lys2ΔA746 reversion rates in wild-type and mutant strains

All frameshiftsComplex frameshiftsNoncomplex frameshifts
StrainRate (×10−9)Rate relative
 to WTRate (×10−10)Rate relative
 to WTRate (×10−10)Rate relative
 to WT
WT3.2 (2.7–3.7)a1.0 1.8 (1.6–2.1)1.030 (25–35)1.0
rad186.3 (5.1–7.7)2.0 15 (12–18)8.348 (39–59)1.6
rad55.0 (4.4–6.9)1.6 14 (13–20)7.838 (33–51)1.3
mms25.2 (4.6–7.1)1.6 11 (10–16)6.139 (34–53)1.3
pol30-464.4 (3.9–5.4)1.4 4.3 (3.9–5.4)2.440 (36–51)1.3
pol327.3 (5.7–9.7)2.30.79 (0.62–1.1)0.4472 (56–96)2.4
rad18 rad53.5 (3.0–4.4)1.10.37b (NA)<0.2135 (30–44)1.2
rad18 mms25.4 (3.9–8.1)1.7 16 (12–24)8.938 (27–57)1.3
  • a Values within parentheses are 95% confidence intervals.

  • b Maximum theoretical rate calculated as if one event had been detected.

  • The category of “all frameshifts” refers to the overall reversion rate. The rates of complex and noncomplex frameshifts were calculated by multiplying the percentage of times the specific frameshift event occurred by the corresponding overall reversion rate. WT, wild type; NA, not applicable.