TABLE 1

Complexes overrepresented among 184 haploinsufficient genes

Complex nameGO complex IDNo. of haploinsufficient genes (total genes
 in complex)Enrichment
 P-valuea
Chaperonin-containing T-complex5832 7 (8)1.1e-10
DNA-directed RNA polymerase II, core complex5665 7 (12)4.9e-08
Exosome (RNAse complex) 178 6 (13)5.5e-06
Ribosome584079 (273)2.2e-16
Small nucleolar ribonucleoprotein complex573211 (31)6.4e-09
  • a Enrichment was calculated by the hypergeometric distribution, with Bonferroni correction for number of complexes tested (167).