TABLE 2

DHSMAP allele age estimates (in generations) for different mutation rates

Details of estimateHFE SNP alleles/frequency
Marker seta μ b 4600G/0.06C282Y/0.07709T/0.117633A/0.117522C/0.13H63D/0.16857A/0.241972T/0.30
A1 + 3VASc 529 138 939 78 1030 1722 986 855
B1VAS516138109585149618301265785
C1 + 31045641411207811316206613011162
D11045481431545902029227214411070
E2 + 410336688558476661029477543
F1103249N/Ad45558455538315357
G1 + 31056521511499841667270915261687
H11056381562262972931386617791578
  • a Marker sets: 1, All SSRs; 2, centromeric SSRs; 3, non-SSR markers (centromeric markers and HFE SNPs); 4 HFE SNPs.

  • b SSR mutation rate assumed; the mutation rate of all non-SSR loci was set to 5 × 107.

  • c Mutation rate estimated from variance in allele size (Valdes et al. 1993); for most markers this was ~104 Table 1).

  • d N/A: DHSMAP failed to estimate an allele age.