TABLE 2

Spontaneous lacI mutations from liver of Big Blue mice

1.5 mo6 mo12 mo18 mo25 mo
No.%% at CpGNo.%% at CpGNo.%% at CpGNo.%% at CpGNo.%% at CpG
Transitions
G:C → A:T2836.471.43733.967.65033.662.02237.363.63241.662.5
A:T → G:C33.91311.91610.758.511.3
Transversions
G:C → T:A2329.965.22522.944.03422.850.01322.038.51722.135.3
G:C → C:G67.850.054.680.085.437.523.4100.011.30.0
A:T → T:A45.232.874.723.456.5
A:T → C:G11.300.064.046.822.6
Other mutations
+1 frameshift22.665.564.011.700.0
→ 1 frameshift33.91311.985.423.445.2
Deletions45.232.853.411.779.1
Insertions00.021.832.000.011.3
Complex changes00.000.032.000.000.0
Double mutants33.921.832.0711.979.1
Totala771001091001491005910077100
  • a The total numbers of mutants after correction for clonality (see materials and methods). The noncorrected mutant totals were 84 at 1.5 mo, 131 at 6 mo, 170 at 12 mo, 69 at 18 mo, and 86 at 25 mo.