TABLE 1

Summary of mutations in the fl alleles

AlleleDescription of the mutation
f1LDeletion of nucleotides 497–564 removes the first 20 amino acids, including the translational start codon.
f1PDuplication of nucleotides 1293–1339 results in a frameshift after codon T230.
f1P961Insertion of a base pair after nucleotide 938 causes a frameshift after codon D96.
f1YTransition mutations at nucleotides 519 and 1591 result in codon changes of threonine to serine at amino acid 7 and arginine to lysine at amino acid 314.
f1RIPRIP allele has 105 transition mutations that result in the following codon changes in fl:
M1IaS150NG221SE270KA307TM405IG476R
R3KG154SE225KR274HG310SG410SD492N
C14YD161NW231ZbC276YW348ZE412KM493I
D22NS168ND237NE278KW352ZE416KW505Z
C37YR182KC253YC289YV367IE418KM529I
M1161M194IC257YM302IE370KR425Q
G149SS203NM265IG305RR390TV454M
  • a M1I indicates that methionine (M) at codon 1 is mutated to isoleucine (I).

  • b Z is the symbol used to represent a stop codon.