TY - JOUR
T1 - Unbiased Estimator for Genetic Drift and Effective Population Size
JF - Genetics
JO - Genetics
SP - 927
LP - 935
DO - 10.1534/genetics.107.075481
VL - 177
IS - 2
AU - Jorde, Per Erik
AU - Ryman, Nils
Y1 - 2007/10/01
UR - http://www.genetics.org/content/177/2/927.abstract
N2 - Amounts of genetic drift and the effective size of populations can be estimated from observed temporal shifts in sample allele frequencies. Bias in this so-called temporal method has been noted in cases of small sample sizes and when allele frequencies are highly skewed. We characterize bias in commonly applied estimators under different sampling plans and propose an alternative estimator for genetic drift and effective size that weights alleles differently. Numerical evaluations of exact probability distributions and computer simulations verify that this new estimator yields unbiased estimates also when based on a modest number of alleles and loci. At the cost of a larger standard deviation, it thus eliminates the bias associated with earlier estimators. The new estimator should be particularly useful for microsatellite loci and panels of SNPs, representing a large number of alleles, many of which will occur at low frequencies.
ER -