PT - JOURNAL ARTICLE
AU - Dupuis, JosÃ©e
AU - Siegmund, David
TI - Statistical Methods for Mapping Quantitative Trait Loci From a Dense Set of Markers
DP - 1999 Jan 01
TA - Genetics
PG - 373--386
VI - 151
IP - 1
4099 - http://www.genetics.org/content/151/1/373.short
4100 - http://www.genetics.org/content/151/1/373.full
SO - Genetics1999 Jan 01; 151
AB - Lander and Botstein introduced statistical methods for searching an entire genome for quantitative trait loci (QTL) in experimental organisms, with emphasis on a backcross design and QTL having only additive effects. We extend their results to intercross and other designs, and we compare the power of the resulting test as a function of the magnitude of the additive and dominance effects, the sample size and intermarker distances. We also compare three methods for constructing confidence regions for a QTL: likelihood regions, Bayesian credible sets, and support regions. We show that with an appropriate evaluation of the coverage probability a support region is approximately a confidence region, and we provide a theroretical explanation of the empirical observation that the size of the support region is proportional to the sample size, not the square root of the sample size, as one might expect from standard statistical theory.