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Chromatin Organization and Remodeling of Interstitial Telomeric Sites During Meiosis in the Mongolian Gerbil (Meriones unguiculatus)

Roberto de la Fuente, Marcia Manterola, Alberto Viera, María Teresa Parra, Manfred Alsheimer, Julio S. Rufas and Jesús Page
Genetics Early online June 6, 2014; https://doi.org/10.1534/genetics.114.166421
Roberto de la Fuente
Stowers Institute for Medical Research; Universidad Autónoma de Madrid;
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Marcia Manterola
Columbia University Medical Center;
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Alberto Viera
Universidad Autónoma de Madrid;
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María Teresa Parra
Universidad Autónoma de Madrid;
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Manfred Alsheimer
University of Würzburg
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Julio S. Rufas
Universidad Autónoma de Madrid;
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Jesús Page
Universidad Autónoma de Madrid;
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Abstract

Telomeric DNA repeats are key features of chromosomes that allow the maintenance of integrity and stability in the telomeres. However, interstitial telomere sites (ITSs) can also be found along the chromosomes, especially near the centromere, where they may appear following chromosomal rearrangements like Robertsonian translocations. There is no defined role for ITSs, but they are linked to DNA damage-prone sites. We were interested in studying the structural organization of ITSs during meiosis, a kind of cell division in which programmed DNA damage events and noticeable chromatin reorganizations occur. Here we describe the presence of highly amplified ITSs in the pericentromeric region of Mongolian gerbil (Meriones unguiculatus) chromosomes. During meiosis, ITSs show a different chromatin conformation than DNA repeats at telomeres, appearing more extended and accumulating heterochromatin markers. Interestingly, ITSs also recruit the telomeric proteins RAP1 and TRF1, but in a stage-dependent manner, appearing mainly at late prophase I stages. We did not find a specific accumulation of DNA repair factors to the ITSs, such as γH2AX or RAD51 at these stages, but we could detect the presence of MLH1, a marker for reciprocal recombination. However, contrary to previous reports, we did not find a specific accumulation of crossovers at ITSs. Intriguingly, some centromeric regions of metacentric chromosomes may bind the nuclear envelope through the association to SUN1 protein, a feature usually performed by telomeres. Therefore, ITSs present a particular and dynamic chromatin configuration in meiosis, which could be involved in maintaining their genetic stability, but they additionally retain some features of distal telomeres, provided by their capability to associate to telomere-binding proteins.

  • Mongolian gerbil
  • RAP1
  • chromatin
  • interstitial telomeres
  • meiosis
  • Received March 12, 2014.
  • Accepted June 1, 2014.
  • Copyright © 2014, The Genetics Society of America
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Volume 208 Issue 4, April 2018

Genetics: 208 (4)

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Chromatin Organization and Remodeling of Interstitial Telomeric Sites During Meiosis in the Mongolian Gerbil (Meriones unguiculatus)

Roberto de la Fuente, Marcia Manterola, Alberto Viera, María Teresa Parra, Manfred Alsheimer, Julio S. Rufas and Jesús Page
Genetics Early online June 6, 2014; https://doi.org/10.1534/genetics.114.166421
Roberto de la Fuente
Stowers Institute for Medical Research; Universidad Autónoma de Madrid;
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Marcia Manterola
Columbia University Medical Center;
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Alberto Viera
Universidad Autónoma de Madrid;
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María Teresa Parra
Universidad Autónoma de Madrid;
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Manfred Alsheimer
University of Würzburg
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Julio S. Rufas
Universidad Autónoma de Madrid;
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Jesús Page
Universidad Autónoma de Madrid;
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  • For correspondence: jesus.page@uam.es
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Citation

Chromatin Organization and Remodeling of Interstitial Telomeric Sites During Meiosis in the Mongolian Gerbil (Meriones unguiculatus)

Roberto de la Fuente, Marcia Manterola, Alberto Viera, María Teresa Parra, Manfred Alsheimer, Julio S. Rufas and Jesús Page
Genetics Early online June 6, 2014; https://doi.org/10.1534/genetics.114.166421
Roberto de la Fuente
Stowers Institute for Medical Research; Universidad Autónoma de Madrid;
  • Find this author on Google Scholar
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  • Search for this author on this site
Marcia Manterola
Columbia University Medical Center;
  • Find this author on Google Scholar
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Alberto Viera
Universidad Autónoma de Madrid;
  • Find this author on Google Scholar
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María Teresa Parra
Universidad Autónoma de Madrid;
  • Find this author on Google Scholar
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Manfred Alsheimer
University of Würzburg
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Julio S. Rufas
Universidad Autónoma de Madrid;
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Jesús Page
Universidad Autónoma de Madrid;
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  • For correspondence: jesus.page@uam.es

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