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The Extracellular Matrix Protein Artichoke Is Required for Integrity of Ciliated Mechanosensory and Chemosensory Organs in Drosophila Embryos

Marta Andrés, Enrique Turiégano, Martin C. Göpfert, Inmaculada Canal and Laura Torroja
Genetics Early online February 4, 2014; https://doi.org/10.1534/genetics.113.156323
Marta Andrés
University of Göttingen; Universidad Autónoma de Madrid;
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Enrique Turiégano
Universidad Autónoma de Madrid;
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Martin C. Göpfert
University of Göttingen
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Inmaculada Canal
Universidad Autónoma de Madrid;
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Laura Torroja
Universidad Autónoma de Madrid;
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  • For correspondence: laura.torroja@uam.es
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Abstract

Sensory cilia are often encapsulated by an extracellular matrix (ECM). In Caenorhabditis elegans, Drosophila melanogaster, and vertebrates, this ECM is thought to be directly involved in ciliary mechanosensing by coupling external forces to the ciliary membrane. Drosophila mechano- and chemosensory cilia are both associated with an ECM, indicating that the ECM may have additional roles that go beyond mechanosensory cilium function. Here, we identify Artichoke (ATK), an evolutionary conserved leucine-rich repeat ECM protein that is required for normal morphogenesis and function of ciliated sensilla in Drosophila. atk is transiently expressed in accessory cells in all ciliated sensory organs during their late embryonic development. Antibody stainings show ATK protein in the ECM that surrounds sensory cilia. Loss of ATK protein in atk null mutants leads to cilium deformation and disorientation in chordotonal organs, apparently without uncoupling the cilia from the ECM, and consequently to locomotion defects. Moreover, impaired chemotaxis in atk mutant larvae suggests that, based on ATK protein localization, the ECM is also crucial for the correct assembly of chemosensory receptors. In addition to defining a novel ECM component, our findings show the importance of ECM integrity for the proper morphogenesis of ciliated organs in different sensory modalities.

  • LRR proteins
  • chordotonal organ
  • dendritic cap
  • extracellular matrix
  • sensory cilium
  • Received August 9, 2013.
  • Accepted January 26, 2014.
  • Copyright © 2014, The Genetics Society of America
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Volume 208 Issue 4, April 2018

Genetics: 208 (4)

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The Extracellular Matrix Protein Artichoke Is Required for Integrity of Ciliated Mechanosensory and Chemosensory Organs in Drosophila Embryos

Marta Andrés, Enrique Turiégano, Martin C. Göpfert, Inmaculada Canal and Laura Torroja
Genetics Early online February 4, 2014; https://doi.org/10.1534/genetics.113.156323
Marta Andrés
University of Göttingen; Universidad Autónoma de Madrid;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Enrique Turiégano
Universidad Autónoma de Madrid;
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Martin C. Göpfert
University of Göttingen
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Inmaculada Canal
Universidad Autónoma de Madrid;
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Laura Torroja
Universidad Autónoma de Madrid;
  • Find this author on Google Scholar
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  • Search for this author on this site
  • For correspondence: laura.torroja@uam.es
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Citation

The Extracellular Matrix Protein Artichoke Is Required for Integrity of Ciliated Mechanosensory and Chemosensory Organs in Drosophila Embryos

Marta Andrés, Enrique Turiégano, Martin C. Göpfert, Inmaculada Canal and Laura Torroja
Genetics Early online February 4, 2014; https://doi.org/10.1534/genetics.113.156323
Marta Andrés
University of Göttingen; Universidad Autónoma de Madrid;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Enrique Turiégano
Universidad Autónoma de Madrid;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin C. Göpfert
University of Göttingen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Inmaculada Canal
Universidad Autónoma de Madrid;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laura Torroja
Universidad Autónoma de Madrid;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: laura.torroja@uam.es

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