The flk1 mutation, which was originally isolated in the yeast Saccharomyces cadsbergenesis, causes insensitivity to catabolite repression. This mutation has been further characterized and mapped. The gene flkl is located on chromosome III between thr4 and MAL2,14 centimorgans from MAL2. flk1 is shown to be allelic to the pleiotropic mutants tupl, cyc9, and umr7; and flk1 is shown to exhibit an array of pleiotropic properties common to tupl, cyc9 and umr7; These results suggest that the flkl mutation is not a specific lesion affecting catabolite repression.
- Received May 21, 1979.