Experimental data and theoretical work on the inheritance of handedness and cerebral dominance are reviewed. A two-gene, four-allele model, one locus pertaining to left or right hemispheric dominance and the other to contralateral or ipsilateral hand control relative to the dominant hemisphere, is constructed. It is in excellent agreement with all quantitative information regarding this problem. Refinements designed to explain relevant qualitative facts are proposed and discussed.

  • Received August 30, 1971.