Skip to main content
  • Facebook
  • Twitter
  • YouTube
  • LinkedIn
  • Google Plus
  • Other GSA Resources
    • Genetics Society of America
    • G3: Genes | Genomes | Genetics
    • Genes to Genomes: The GSA Blog
    • GSA Conferences
    • GeneticsCareers.org
  • Log in
Genetics

Main menu

  • HOME
  • ISSUES
    • Current Issue
    • Early Online
    • Archive
  • ABOUT
    • About the journal
    • Why publish with us?
    • Editorial board
    • Contact us
  • SERIES
    • Centennial
    • Genetics of Immunity
    • Genetics of Sex
    • Genomic Selection
    • Multiparental Populations
    • FlyBook
    • WormBook
    • YeastBook
  • ARTICLE TYPES
    • About Article Types
    • Commentaries
    • Editorials
    • GSA Honors and Awards
    • Methods, Technology & Resources
    • Perspectives
    • Primers
    • Reviews
    • Toolbox Reviews
  • PUBLISH & REVIEW
    • Scope & publication policies
    • Submission & review process
    • Article types
    • Prepare your manuscript
    • Submit your manuscript
    • After acceptance
    • Guidelines for reviewers
  • SUBSCRIBE
    • Why subscribe?
    • For institutions
    • For individuals
    • Email alerts
    • RSS feeds
  • Other GSA Resources
    • Genetics Society of America
    • G3: Genes | Genomes | Genetics
    • Genes to Genomes: The GSA Blog
    • GSA Conferences
    • GeneticsCareers.org

User menu

Search

  • Advanced search
Genetics

Advanced Search

  • HOME
  • ISSUES
    • Current Issue
    • Early Online
    • Archive
  • ABOUT
    • About the journal
    • Why publish with us?
    • Editorial board
    • Contact us
  • SERIES
    • Centennial
    • Genetics of Immunity
    • Genetics of Sex
    • Genomic Selection
    • Multiparental Populations
    • FlyBook
    • WormBook
    • YeastBook
  • ARTICLE TYPES
    • About Article Types
    • Commentaries
    • Editorials
    • GSA Honors and Awards
    • Methods, Technology & Resources
    • Perspectives
    • Primers
    • Reviews
    • Toolbox Reviews
  • PUBLISH & REVIEW
    • Scope & publication policies
    • Submission & review process
    • Article types
    • Prepare your manuscript
    • Submit your manuscript
    • After acceptance
    • Guidelines for reviewers
  • SUBSCRIBE
    • Why subscribe?
    • For institutions
    • For individuals
    • Email alerts
    • RSS feeds
Previous ArticleNext Article

The Spread of an Inversion with Migration and Selection

View ORCID ProfileBrian Charlesworth and View ORCID ProfileNicholas H. Barton
Genetics January 1, 2018 vol. 208 no. 1 377-382; https://doi.org/10.1534/genetics.117.300426
Brian Charlesworth
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, EH9 3FL, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Brian Charlesworth
  • For correspondence: Brian.Charlesworth@ed.ac.uk
Nicholas H. Barton
Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nicholas H. Barton
  • Article
  • Figures & Data
  • Info & Metrics
Loading

This article has a correction. Please see:

  • Chromosome Inversions, Local Adaptation and Speciation - January 01, 2018

Abstract

We re-examine the model of Kirkpatrick and Barton for the spread of an inversion into a local population. This model assumes that local selection maintains alleles at two or more loci, despite immigration of alternative alleles at these loci from another population. We show that an inversion is favored because it prevents the breakdown of linkage disequilibrium generated by migration; the selective advantage of an inversion is dependent on the amount of recombination between the loci involved, as in other cases where inversions are selected for as a result of their effects on recombination. We derive expressions for the rate of spread of an inversion; when the loci covered by the inversion are tightly linked, these conditions deviate substantially from those proposed previously, and imply that an inversion can then have only a small advantage.

  • inversion
  • linkage disequilibrium
  • migration
  • recombination
  • selection
  • Received October 23, 2017.
  • Accepted November 14, 2017.
  • Copyright © 2018 by the Genetics Society of America
View Full Text

Log in using your username and password

Forgot your user name or password?
Previous ArticleNext Article
Back to top

PUBLICATION INFORMATION

Volume 208 Issue 1, January 2018

Genetics: 208 (1)

ARTICLE CLASSIFICATION

INVESTIGATIONS
Population and evolutionary genetics
View this article with LENS
Email

Thank you for sharing this Genetics article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
The Spread of an Inversion with Migration and Selection
(Your Name) has forwarded a page to you from Genetics
(Your Name) thought you would be interested in this article in Genetics.
Print
Alerts
Enter your email below to set up alert notifications for new article, or to manage your existing alerts.
SIGN UP OR SIGN IN WITH YOUR EMAIL
View PDF
Share

The Spread of an Inversion with Migration and Selection

View ORCID ProfileBrian Charlesworth and View ORCID ProfileNicholas H. Barton
Genetics January 1, 2018 vol. 208 no. 1 377-382; https://doi.org/10.1534/genetics.117.300426
Brian Charlesworth
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, EH9 3FL, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Brian Charlesworth
  • For correspondence: Brian.Charlesworth@ed.ac.uk
Nicholas H. Barton
Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nicholas H. Barton
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation

The Spread of an Inversion with Migration and Selection

View ORCID ProfileBrian Charlesworth and View ORCID ProfileNicholas H. Barton
Genetics January 1, 2018 vol. 208 no. 1 377-382; https://doi.org/10.1534/genetics.117.300426
Brian Charlesworth
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, EH9 3FL, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Brian Charlesworth
  • For correspondence: Brian.Charlesworth@ed.ac.uk
Nicholas H. Barton
Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nicholas H. Barton

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Related Articles

Cited By

More in this TOC Section

Investigations

  • Mitotic and Meiotic Functions for the SUMOylation Pathway in the Caenorhabditis elegans Germline
  • Plasticity of Meiotic Recombination Rates in Response to Temperature in Arabidopsis
  • Seven-Up Is a Novel Regulator of Insulin Signaling
Show more 3

Population and Evolutionary Genetics

  • RNA-Interference Pathways Display High Rates of Adaptive Protein Evolution in Multiple Invertebrates
  • Detecting Polygenic Adaptation in Admixture Graphs
  • A Population Phylogenetic View of Mitochondrial Heteroplasmy
Show more 3
  • Top
  • Article
    • Abstract
    • Results for Two Selected Loci with Low Migration
    • Discussion
    • Acknowledgments
    • Appendix
    • Footnotes
    • Literature Cited
  • Figures & Data
  • Info & Metrics

GSA

The Genetics Society of America (GSA), founded in 1931, is the professional membership organization for scientific researchers and educators in the field of genetics. Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level.

Online ISSN: 1943-2631

  • For Authors
  • For Reviewers
  • For Subscribers
  • Submit a Manuscript
  • Editorial Board
  • Press Releases

SPPA Logo

GET CONNECTED

RSS  Subscribe with RSS.

email  Subscribe via email. Sign up to receive alert notifications of new articles.

  • Facebook
  • Twitter
  • YouTube
  • LinkedIn
  • Google Plus

Copyright © 2018 by the Genetics Society of America

  • About GENETICS
  • Terms of use
  • Advertising
  • Permissions
  • Contact us
  • International access