February 2017 Table of Contents

Investigations

• Methods, Technology, And Resources

  • Improving the Identification of Phenotypic Abnormalities and Sexual Dimorphism in Mice When Studying Rare Event Categorical Characteristics

    Open Access

    Natasha A. Karp, Ruth Heller, Shay Yaacoby, Jacqueline K. White, Yoav Benjamini

    Genetics February 2017 205: 491-501; https://doi.org/10.1534/genetics.116.195388

• Genome Integrity And Transmission

  • Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice

    Open Access

    João Luís Neto, Jong-Min Lee, Ali Afridi, Tammy Gillis, Jolene R. Guide, Stephani Dempsey, Brenda Lager, Isabel Alonso, Vanessa C. Wheeler, Ricardo Mouro Pinto

    Genetics February 2017 205: 503-516; https://doi.org/10.1534/genetics.116.195578
  • Cooperation Between Kinesin Motors Promotes Spindle Symmetry and Chromosome Organization in Oocytes

    Sarah J. Radford, Allysa Marie M. Go, Kim S. McKim

    Genetics February 2017 205: 517-527; https://doi.org/10.1534/genetics.116.194647
  • Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog

    Adrian J. McNairn, Vera D. Rinaldi, John C. Schimenti

    Genetics February 2017 205: 529-537; https://doi.org/10.1534/genetics.116.196808

• Gene Expression

  • The Role of +4U as an Extended Translation Termination Signal in Bacteria

    Open Access

    Yulong Wei, Xuhua Xia

    Genetics February 2017 205: 539-549; https://doi.org/10.1534/genetics.116.193961
  • An Unexpected Regulatory Cascade Governs a Core Function of the Drosophila PRC1 Chromatin Protein Su(z)2

    Son C. Nguyen, Stephanie Yu, Elaine Oberlick, Chao-ting Wu

    Genetics February 2017 205: 551-558; https://doi.org/10.1534/genetics.116.187849
  • Zinc Cluster Transcription Factors Alter Virulence in Candida albicans

    Luca Issi, Rhys A. Farrer, Kelly Pastor, Benjamin Landry, Toni Delorey, George W. Bell, Dawn A. Thompson, Christina A. Cuomo, Reeta P. Rao

    Genetics February 2017 205: 559-576; https://doi.org/10.1534/genetics.116.195024
  • The Promiscuous sumA Missense Suppressor from Salmonella enterica Has an Intriguing Mechanism of Action

    Ashley E. Cole, Fatmah M. Hani, Ronni Altman, Megan Meservy, John R. Roth, Elliot Altman

    Genetics February 2017 205: 577-588; https://doi.org/10.1534/genetics.116.196550
  • Different Evolutionary Strategies To Conserve Chromatin Boundary Function in the Bithorax Complex

    Open Access

    Fabienne Cleard, Daniel Wolle, Andrew M. Taverner, Tsutomu Aoki, Girish Deshpande, Peter Andolfatto, Francois Karch, Paul Schedl

    Genetics February 2017 205: 589-603; https://doi.org/10.1534/genetics.116.195586
  • Stable Binding of the Conserved Transcription Factor Grainy Head to its Target Genes Throughout Drosophila melanogaster Development

    Markus Nevil, Eliana R. Bondra, Katharine N. Schulz, Tommy Kaplan, Melissa M. Harrison

    Genetics February 2017 205: 605-620; https://doi.org/10.1534/genetics.116.195685
  • Multiple Transcriptional and Post-transcriptional Pathways Collaborate to Control Sense and Antisense RNAs of Tf2 Retroelements in Fission Yeast

    Pierre-Luc Mallet, Marc Larochelle, François Bachand

    Genetics February 2017 205: 621-632; https://doi.org/10.1534/genetics.116.193870
  • General Amino Acid Control and 14-3-3 Proteins Bmh1/2 Are Required for Nitrogen Catabolite Repression-Sensitive Regulation of Gln3 and Gat1 Localization

    Jennifer J. Tate, David Buford, Rajendra Rai, Terrance G. Cooper

    Genetics February 2017 205: 633-655; https://doi.org/10.1534/genetics.116.195800

• Cellular Genetics

  • Meiotic Centromere Coupling and Pairing Function by Two Separate Mechanisms in Saccharomyces cerevisiae

    Emily L. Kurdzo, David Obeso, Hoa Chuong, Dean S. Dawson

    Genetics February 2017 205: 657-671; https://doi.org/10.1534/genetics.116.190264
  • Traffic Through the Trans-Golgi Network and the Endosomal System Requires Collaboration Between Exomer and Clathrin Adaptors in Fission Yeast

    Marta Hoya, Francisco Yanguas, Sandra Moro, Cristina Prescianotto-Baschong, Cristina Doncel, Nagore de León, M.-Ángeles Curto, Anne Spang, M.-Henar Valdivieso

    Genetics February 2017 205: 673-690; https://doi.org/10.1534/genetics.116.193458
  • Evidence for Amino Acid Snorkeling from a High-Resolution, In Vivo Analysis of Fis1 Tail-Anchor Insertion at the Mitochondrial Outer Membrane

    Open Access

    Abdurrahman Keskin, Emel Akdoğan, Cory D. Dunn

    Genetics February 2017 205: 691-705; https://doi.org/10.1534/genetics.116.196428

• Developmental and Behavioral Genetics

  • Human SOD1 ALS Mutations in a Drosophila Knock-In Model Cause Severe Phenotypes and Reveal Dosage-Sensitive Gain- and Loss-of-Function Components

    Aslı Şahin, Aaron Held, Kirsten Bredvik, Paxton Major, Toni-Marie Achilli, Abigail G. Kerson, Kristi Wharton, Geoff Stilwell, Robert Reenan

    Genetics February 2017 205: 707-723; https://doi.org/10.1534/genetics.116.190850
  • A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B

    Ritika Gurung, Yosuke Ono, Sarah Baxendale, Samantha Lin Chiou Lee, Steven Moore, Meredith Calvert, Philip W. Ingham

    Genetics February 2017 205: 725-735; https://doi.org/10.1534/genetics.116.192864
  • The Caenorhabditis elegans NF2/Merlin Molecule NFM-1 Nonautonomously Regulates Neuroblast Migration and Interacts Genetically with the Guidance Cue SLT-1/Slit

    Matthew P. Josephson, Rana Aliani, Megan L. Norris, Matthew E. Ochs, Mahekta Gujar, Erik A. Lundquist

    Genetics February 2017 205: 737-748; https://doi.org/10.1534/genetics.116.191957
  • H₂O₂-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying

    Ananya R. Guntur, Bin Gou, Pengyu Gu, Ruo He, Ulrich Stern, Yang Xiang, Chung-Hui Yang

    Genetics February 2017 205: 749-759; https://doi.org/10.1534/genetics.116.195172
  • Feeding-Related Traits Are Affected by Dosage of the foraging Gene in Drosophila melanogaster

    Aaron M. Allen, Ina Anreiter, Megan C. Neville, Marla B. Sokolowski

    Genetics February 2017 205: 761-773; https://doi.org/10.1534/genetics.116.197939
  • Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans

    Mingxue Cui, Yi Wang, Jonathon Cavaleri, Taylor Kelson, Yudong Teng, Min Han

    Genetics February 2017 205: 775-785; https://doi.org/10.1534/genetics.116.194282

• Population and Evolutionary Genetics

  • The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit

    Casper-Emil T. Pedersen, Kirk E. Lohmueller, Niels Grarup, Peter Bjerregaard, Torben Hansen, Hans R. Siegismund, Ida Moltke, Anders Albrechtsen

    Genetics February 2017 205: 787-801; https://doi.org/10.1534/genetics.116.193821
  • Selection Limits to Adaptive Walks on Correlated Landscapes

    Open Access

    Jorge Pérez Heredia, Barbora Trubenová, Dirk Sudholt, Tiago Paixão

    Genetics February 2017 205: 803-825; https://doi.org/10.1534/genetics.116.189340
  • Evolution of Resistance Against CRISPR/Cas9 Gene Drive

    Robert L. Unckless, Andrew G. Clark, Philipp W. Messer

    Genetics February 2017 205: 827-841; https://doi.org/10.1534/genetics.116.197285
  • Statistical Methods for Identifying Sequence Motifs Affecting Point Mutations

    Yicheng Zhu, Teresa Neeman, Von Bing Yap, Gavin A. Huttley

    Genetics February 2017 205: 843-856; https://doi.org/10.1534/genetics.116.195677
  • Inferring Ancestral Recombination Graphs from Bacterial Genomic Data

    Open Access

    Timothy G. Vaughan, David Welch, Alexei J. Drummond, Patrick J. Biggs, Tessy George, Nigel P. French

    Genetics February 2017 205: 857-870; https://doi.org/10.1534/genetics.116.193425
  • Genomic Trajectories to Desiccation Resistance: Convergence and Divergence Among Replicate Selected Drosophila Lines

    Philippa C. Griffin, Sandra B. Hangartner, Alexandre Fournier-Level, Ary A. Hoffmann

    Genetics February 2017 205: 871-890; https://doi.org/10.1534/genetics.116.187104
  • Correlated Mutations and Homologous Recombination Within Bacterial Populations

    Mingzhi Lin, Edo Kussell

    Genetics February 2017 205: 891-917; https://doi.org/10.1534/genetics.116.189621

• Genetics of Complex Traits

  • Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration

    Open Access

    Felix Grassmann, Iris M. Heid, Bernhard H. F. Weber, International AMD Genomics Consortium (IAMDGC)

    Genetics February 2017 205: 919-924; https://doi.org/10.1534/genetics.116.195966
  • The Genomic Architecture of Interactions Between Natural Genetic Polymorphisms and Environments in Yeast Growth

    Xinzhu Wei, Jianzhi Zhang

    Genetics February 2017 205: 925-937; https://doi.org/10.1534/genetics.116.195487
  • Evaluating Sequence-Based Genomic Prediction with an Efficient New Simulator

    Miguel Pérez-Enciso, Natalia Forneris, Gustavo de los Campos, Andrés Legarra

    Genetics February 2017 205: 939-953; https://doi.org/10.1534/genetics.116.194878
  • Dwarfism and Altered Craniofacial Development in Rabbits Is Caused by a 12.1 kb Deletion at the HMGA2 Locus

    Miguel Carneiro, Dou Hu, John Archer, Chungang Feng, Sandra Afonso, Congying Chen, José A. Blanco-Aguiar, Hervé Garreau, Samuel Boucher, Paula G. Ferreira, Nuno Ferrand, Carl-Johan Rubin, Leif Andersson

    Genetics February 2017 205: 955-965; https://doi.org/10.1534/genetics.116.196667
  • Human Facial Shape and Size Heritability and Genetic Correlations

    Joanne B. Cole, Mange Manyama, Jacinda R. Larson, Denise K. Liberton, Tracey M. Ferrara, Sheri L. Riccardi, Mao Li, Washington Mio, Ophir D. Klein, Stephanie A. Santorico, Benedikt Hallgrímsson, Richard A. Spritz

    Genetics February 2017 205: 967-978; https://doi.org/10.1534/genetics.116.193185
  • Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits

    Michela Traglia, Dina Bseiso, Alexander Gusev, Brigid Adviento, Daniel S. Park, Joel A. Mefford, Noah Zaitlen, Lauren A. Weiss

    Genetics February 2017 205: 979-992; https://doi.org/10.1534/genetics.116.193623
  • Emergence of a Novel Chimeric Gene Underlying Grain Number in Rice

    Hao Chen, Yanyan Tang, Jianfeng Liu, Lubin Tan, Jiahuan Jiang, Mumu Wang, Zuofeng Zhu, Xianyou Sun, Chuanqing Sun

    Genetics February 2017 205: 993-1002; https://doi.org/10.1534/genetics.116.188201