Attack of the 50-foot Mosquito: Artist Kent Smith's science fiction-inspired take on an out-of-control gene drive system. Recent developments such as CRISPR/Cas9 mediated gene drive have made the prospects for whole population genetic engineering possible. The host population is, however, likely to fight back if the engineered mutations are costly. See Unckless, Clark, and Messer. Artwork by Kent Smith (www.smittytown.com).