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Insights into Three Whole-Genome Duplications Gleaned from the Paramecium caudatum Genome Sequence

Casey L. McGrath, Jean-Francois Gout, Thomas G. Doak, Akira Yanagi and Michael Lynch
Genetics August 1, 2014 vol. 197 no. 4 1417-1428; https://doi.org/10.1534/genetics.114.163287
Casey L. McGrath
Department of Biology, Indiana University
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Jean-Francois Gout
Department of Biology, Indiana University
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Thomas G. Doak
Department of Biology, Indiana UniversityNational Center for Genome Analysis Support at Indiana University, Bloomington, Indiana 47405
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Akira Yanagi
Department of Human Education Faculty of Human Studies Ishinomaki Senshu University Ishinomaki 986-8580, Japan
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Michael Lynch
Department of Biology, Indiana University
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  • For correspondence: milynch@indiana.edu
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Data supplements

  • Files in this data supplement:

    • Supporting Information: Figures S1-S3, Files S1-S6, and Tables S1-S3 (PDF, 135 KB)
    • Figure S1: Distributions of dN (A), dS (B), and dN/dS (C) among intermediate WGD duplicates. (PDF, 100 KB)
    • Figure S2: Relationship between log expression level and GC content of caudatum genes. (PDF, 31 KB)
    • Figure S3: Relationship between evolutionary rate (dN computed between P. caudatum / P. multimicronucleatum orthologs) and post-recent-WGD retention rate in three P. aurelia species. (PDF, 13 KB)
    • File S1: Excel file containing orthologous blocks between caudatum genes and recreated pre-recent WGD aurelia segments. (.xls, 3 MB)
    • File S2: Excel file containing orthologous blocks between caudatum genes and recreated pre-intermediate WGD aurelia segments. (.xls, 2 MB)
    • File S3: Excel file containing number of intermediate WGD duplicates vs. single-copy genes in each GO term functional category and P-values. (.xls, 23 KB)
    • File S4: Excel file containing candidates for neofunctionalization from biaurelia, tetraurelia, and sexaurelia. (.xls, 32 KB)
    • File S5: Excel file containing paralogous blocks within caudatum from the ancient WGD. (.xls, 132 KB)
    • File S6: Excel file containing number of ancient WGD duplicates vs. single-copy genes in each GO term functional category and P-values. (.xls, 17 KB)
    • Table S1: Genome assembly and annotation statistics for P. caudatum, as compared to biaurelia (McGrath et al., submitted), tetraurelia (Aury et al. 2006) and sexaurelia (McGrath et al., submitted). (PDF, 7 KB)
    • Table S2: Divergent resolutions of intermediate WGD duplicates between aurelia species. (PDF, 8 KB)
    • Table S3: Average GC content and log expression level for duplicated vs. single-copy caudatum genes from the ancient WGD. (PDF, 7 KB)
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PUBLICATION INFORMATION

Volume 197 Issue 4, August 2014

Genetics: 197 (4)

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Genome and systems biology
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Insights into Three Whole-Genome Duplications Gleaned from the Paramecium caudatum Genome Sequence

Casey L. McGrath, Jean-Francois Gout, Thomas G. Doak, Akira Yanagi and Michael Lynch
Genetics August 1, 2014 vol. 197 no. 4 1417-1428; https://doi.org/10.1534/genetics.114.163287
Casey L. McGrath
Department of Biology, Indiana University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean-Francois Gout
Department of Biology, Indiana University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas G. Doak
Department of Biology, Indiana UniversityNational Center for Genome Analysis Support at Indiana University, Bloomington, Indiana 47405
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akira Yanagi
Department of Human Education Faculty of Human Studies Ishinomaki Senshu University Ishinomaki 986-8580, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Lynch
Department of Biology, Indiana University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: milynch@indiana.edu
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Citation

Insights into Three Whole-Genome Duplications Gleaned from the Paramecium caudatum Genome Sequence

Casey L. McGrath, Jean-Francois Gout, Thomas G. Doak, Akira Yanagi and Michael Lynch
Genetics August 1, 2014 vol. 197 no. 4 1417-1428; https://doi.org/10.1534/genetics.114.163287
Casey L. McGrath
Department of Biology, Indiana University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean-Francois Gout
Department of Biology, Indiana University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas G. Doak
Department of Biology, Indiana UniversityNational Center for Genome Analysis Support at Indiana University, Bloomington, Indiana 47405
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akira Yanagi
Department of Human Education Faculty of Human Studies Ishinomaki Senshu University Ishinomaki 986-8580, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Lynch
Department of Biology, Indiana University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: milynch@indiana.edu

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