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Allelic Diversity and Its Implications for the Rate of Adaptation

Armando Caballero and Aurora García-Dorado
Genetics December 1, 2013 vol. 195 no. 4 1373-1384; https://doi.org/10.1534/genetics.113.158410
Armando Caballero
Departamento de Bioquímica, Genética e Inmunología, Facultad de Biología, Universidad de Vigo, 36310 Vigo, Spain
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Aurora García-Dorado
Departamento de Genética, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, 28080 Madrid, Spain
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  • For correspondence: armando@uvigo.es
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Abstract

Genetic variation is usually estimated empirically from statistics based on population gene frequencies, but alternative statistics based on allelic diversity (number of allelic types) can provide complementary information. There is a lack of knowledge, however, on the evolutionary implications attached to allelic-diversity measures, particularly in structured populations. In this article we simulated multiple scenarios of single and structured populations in which a quantitative trait subject to stabilizing selection is adapted to different fitness optima. By forcing a global change in the optima we evaluated which diversity variables are more strongly correlated with both short- and long-term adaptation to the new optima. We found that quantitative genetic variance components for the trait and gene-frequency-diversity measures are generally more strongly correlated with short-term response to selection, whereas allelic-diversity measures are more correlated with long-term and total response to selection. Thus, allelic-diversity variables are better predictors of long-term adaptation than gene-frequency variables. This observation is also extended to unlinked neutral markers as a result of the information they convey on the demographic population history. Diffusion approximations for the allelic-diversity measures in a finite island model under the infinite-allele neutral mutation model are also provided.

  • number of alleles
  • gene diversity
  • heterozygosity
  • response to selection
  • selection limits
  • diffusion approximations
  • Received May 9, 2013.
  • Accepted October 8, 2013.
  • Copyright © 2013 by the Genetics Society of America
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PUBLICATION INFORMATION

Volume 195 Issue 4, December 2013

Genetics: 195 (4)

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Population and evolutionary genetics
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Allelic Diversity and Its Implications for the Rate of Adaptation

Armando Caballero and Aurora García-Dorado
Genetics December 1, 2013 vol. 195 no. 4 1373-1384; https://doi.org/10.1534/genetics.113.158410
Armando Caballero
Departamento de Bioquímica, Genética e Inmunología, Facultad de Biología, Universidad de Vigo, 36310 Vigo, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aurora García-Dorado
Departamento de Genética, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, 28080 Madrid, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: armando@uvigo.es
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Citation

Allelic Diversity and Its Implications for the Rate of Adaptation

Armando Caballero and Aurora García-Dorado
Genetics December 1, 2013 vol. 195 no. 4 1373-1384; https://doi.org/10.1534/genetics.113.158410
Armando Caballero
Departamento de Bioquímica, Genética e Inmunología, Facultad de Biología, Universidad de Vigo, 36310 Vigo, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aurora García-Dorado
Departamento de Genética, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, 28080 Madrid, Spain
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: armando@uvigo.es

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The Genetics Society of America (GSA), founded in 1931, is the professional membership organization for scientific researchers and educators in the field of genetics. Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level.

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