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Visualization of the metabolic network of Saccharomyces cerevisiae. Blue nodes represent genes, and green nodes represent enzymatic reactions. The three highlighted nodes were identified by an in silico screen as knockout candidates for the production of formic acid. Although the three genes appear unrelated, deletion of these genes in concert resulted in significant formic acid secretion. The network was constructed using the iND750 model, the COBRA toolbox for MATLAB, and Cytoscape software.
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