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doi:10.1534/genetics.108.089805
A more recent version of this article appeared on July 1, 2008.
REGULAR RESEARCH PAPERS |
Molecular Evolution of Pi-ta Gene Resistance to Rice Blast in Wild Rice (Oryza rufipogon)
Chun-Lin Huang 1, Shih-Ying Hwang 2, Yu-Chung Chiang 3 and Tsan-Piao Lin 1*
1 Institute of Plant Biology, National Taiwan University
2 National Taiwan Normal University
3 Pingtung University of Science and Technology
* To whom correspondence should be addressed. E-mail: tpl{at}ntu.edu.tw.
Submitted on March 31, 2008
Revised on April 29, 2008
Accepted on 14 May 2008
Rice blast disease resistance to the fungal pathogen Magnapothe grisea is triggered by a physical interaction between the protein products of the host R gene Pi-ta and the pathogen Avr (avirulence) gene AVR-pita. The genotype variation and resistant/susceptible phenotype at the Pi-ta locus of wild rice (Oryza rufipogon), the ancestor of cultivated rice, was surveyed in 36 locations worldwide to study the molecular evolution and functional adaptation of the Pi-ta gene. The low nucleotide polymorphism in the Pi-ta gene of wild rice was similar to that of cultivated rice, but greatly differed from what has been reported for other O. rufipogon genes. The haplotypes can be subdivided into two divergent haplogroups named H1 and H2. H1 is derived from H2, with nearly no variation and at a low frequency. H2 is common and the ancestral form. The low polymorphism of Pi-ta gene might be caused by recurrent selective sweep and constraint by unknown putative physiological function. Meanwhile, we provide data to show the amino acid, Ala-918, of H1 in the leucine-rich repeat domain has close relationship with resistant phenotype. H1 might arise recently during rice domestication, and associate with the scenario of the blast pathogen host shift from Italian millet to rice.
Key Words: Pi-ta gene, disease resistance, polymorphism, wild rice
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