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genetics.108.089052v1
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doi:10.1534/genetics.108.089052
A more recent version of this article appeared on August 1, 2008.
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Incorporation of Y'-Ty1 cDNA destabilizes telomeres in Saccharomyces cerevisiae telomerase-negative mutants
Patrick H. Maxwell 1 and M. Joan Curcio 1*
1 Wadsworth Center
* To whom correspondence should be addressed. E-mail: curcio{at}wadsworth.org.
Submitted on March 12, 2008
Revised on April 14, 2008
Accepted on 12 May 2008
Ty1 retrotransposons in Saccharomyces cerevisiae are activated in response to telomere erosion. Ty1-dependent reverse transcription of mRNA from subtelomeric Y' repeats generates chimeric Y'-Ty1 cDNA. Here, we show that Y'-Ty1 cDNA is incorporated at eroding telomeres in the absence of telomerase. Telomeric incorporation of Y'-Ty1 cDNA promotes genome rearrangements.
Key Words: Ty1, Y' repeat, genome rearrangement, reverse transcriptase, telomere
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