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doi:10.1534/genetics.107.083923
A more recent version of this article appeared on February 1, 2008.
REGULAR RESEARCH PAPERS |
DAF-16-Dependent Suppression of Immunity during Reproduction in C. elegans
Sachiko Miyata 1, Jakob Begun 2, Emily R Troemel 1 and Frederick M Ausubel 1*
1 Massachusetts General Hospital
2 Harvard Medical School
* To whom correspondence should be addressed. E-mail: ausubel{at}molbio.mgh.harvard.edu.
Submitted on October 29, 2007
Revised on November 21, 2007
Accepted on 21 November 2007
To further understand how the nematode C. elegans defends itself against pathogen attack, we analyzed enhanced pathogen resistance (epr) mutants obtained from a forward genetic screen. We also examined several well-characterized sterile mutants that exhibit an Epr phenotype. We found that sterility and pathogen resistance are highly correlated and that resistance in both epr and sterile mutants is dependent on DAF-16 activity. Our data indicate that a DAF-16-dependent signaling pathway distinct from previously described pathways is involved in the activation of genes that confer resistance to bacterial pathogens. The timing of DAF-16-dependent gene activation in sterile mutants coincides with the onset of embryonic development in wild-type animals, suggesting that signals from developing embryos normally downregulate the immune response.
Key Words: DAF-16, developing embryos, innate immunity, pathogen resistance, sterility
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