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doi:10.1534/genetics.107.076497
A more recent version of this article appeared on November 1, 2007.
REGULAR RESEARCH PAPERS |
Linkage Mapping of Domestication Loci in a Large Maize-Teosinte Backcross Resource
William Hubbard Briggs 1*, Michael McMullen 2, Brandon Gaut 3 and John Doebley 1
1 University of Wisconsin-Madison
2 USDA-ARS
3 University of California - Irvine
* To whom correspondence should be addressed. E-mail: william.briggs{at}syngenta.com.
Submitted on May 24, 2007
Revised on July 10, 2007
Accepted on 14 September 2007
An ultimate objective of QTL mapping is cloning genes responsible for quantitative traits. However, projects seldom go beyond segments narrower than 5 cM without subsequent breeding and genotyping lines to identify additional crossovers in a genomic region of interest. We report on a QTL analysis performed as a preliminary step in the development of a resource for map-based cloning of domestication and improvement genes in corn. A large BC1 population derived from a cross between maize (Z. mays ssp. mays) and teosinte (ssp. parviglumis) was grown for the analysis. A total of 1749 progenies were genotyped for 304 markers and measured for 22 morphological traits. The results are in agreement with earlier studies showing a small number of genomic regions having greater impact on the morphological traits distinguishing maize and teosinte. Despite considerable power to detect epistasis, few QTL interactions were identified. To create a permanent resource, seed of BC1 plants was archived and 1000 BC2S6 BC1-derived lines are in development for fine mapping and cloning. The identification of four BC1 progeny with crossovers in a single gene, tb1, indicated that enough derived lines already exist to clone many QTL without the need to generate and identify additional crossovers.
Key Words: domestication, epistasis, plant architecture, positional cloning
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