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doi:10.1534/genetics.107.074302
A more recent version of this article appeared on September 1, 2007.
NOTE |
Genetic Dissection of Cytonuclear Epistasis in Line Crosses
Zaixiang Tang 1, Xuefeng Wang 1, Zhiqiu Hu 1, Zefeng Yang 1 and Chenwu Xu 1*
1 Yangzhou University
* To whom correspondence should be addressed. E-mail: qtls{at}yzu.edu.cn.
Submitted on April 9, 2007
Revised on June 13, 2007
Accepted on 2 July 2007
Dissection of cytonuclear interactions is fundamentally important for understanding the genetic architecture of complex traits. Here we propose a mating design based on reciprocal crosses and extend the existing QTL mapping method to evaluate the contribution of cytoplasm and QTL X cytoplasm interactions to the phenotypic variation. Efficiency of the design and method is demonstrated via simulated data.
Key Words: Cytonuclear interaction, Cytoplasm, Epistasis, Quantitative trait loci, Reciprocal Cross