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Jitka Zluvova
Bohuslav Janousek
Boris Vyskot
Ioan Negrutiu
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doi:10.1534/genetics.107.071175
A more recent version of this article appeared on September 1, 2007.
REGULAR RESEARCH PAPERS |
Early events in the evolution of the Silene latifolia Y chromosome: male specialization and recombination arrest
Jitka Zluvova 1, Sevdalin Georgiev 2, Bohuslav Janousek 1, Deborah Charlesworth 3, Boris Vyskot 1 and Ioan Negrutiu 4*
1 Institute of Biophysics Academy of Sciences of the Czech Republic
2 Sofia University
3 University of Edinburgh
4 Ecole Normale Supérieure de Lyon
* To whom correspondence should be addressed. E-mail: ioan.negrutiu{at}ens-lyon.fr.
Submitted on January 19, 2007
Revised on March 6, 2007
Accepted on 12 June 2007
Theories of the early stages of sex chromosome evolution predict that the primary sex determination loci initially arose in a small "proto-Y" region, followed by accumulation of sexually antagonistic mutations with male-benefits in Y chromosome regions linked to the sex-determining genes, creating further selection for suppressed recombination with the X-chromosome homologous regions, eventually preventing recombination across a wide region. Understanding the origin and evolution of sex chromosomes requires studying recently evolved X-Y chromosome systems such as those in some flowering plants. We therefore mapped Y chromosome deletion mutants of Silene latifolia, a dioecious plant with heteromorphic sex chromosomes. By combining the results with histological descriptions of the defects in stamen development, we estimate the number of Y-linked loci indispensable for male reproduction. Cytological analysis of meiotic X-Y pairing also indicates that the Y carries sequences or functions affecting sex chromosome-specific pairing. This supports the hypothesis that recombination was suppressed between the S. latifolia X-Y pair by successive events that expanded an initial non-recombining region around the primary sex-determining genes, consistent with previous evidence that the lack of X-Y pairing is not caused by the inversion that has been inferred in S. latifolia.
Key Words: Silene latifolia, X-Y paring control, Y chromosome, deletion mapping, male-indispensable genes
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