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doi:10.1534/genetics.107.070847
A more recent version of this article appeared on October 1, 2007.
NOTE |
Modulation of C. elegans transcription factor activity by HIM-8 and the related zinc finger ZIM proteins
Hongliu Sun 1, Brian L. Nelms 2, Sama F. Sleiman 3, Helen M. Chamberlin 3 and Wendy Hanna-Rose 1*
1 Penn State
2 Vanderbilt
3 Ohio State
* To whom correspondence should be addressed. E-mail: wxh21{at}psu.edu.
Submitted on January 11, 2007
Revised on February 13, 2007
Accepted on 4 August 2007
The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.
Key Words: chromosome, egl-13, egl-38, gene regulation, lin-39