Genetics. Published Articles Ahead of Print: August 24, 2007, Copyright © 2007
doi:10.1534/genetics.107.070847


A more recent version of this article appeared on October 1, 2007.


NOTE

Modulation of C. elegans transcription factor activity by HIM-8 and the related zinc finger ZIM proteins

1 Penn State
2 Vanderbilt
3 Ohio State

* To whom correspondence should be addressed. E-mail: wxh21{at}psu.edu.

Submitted on January 11, 2007
Revised on February 13, 2007
Accepted on 4 August 2007


Abstract

The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.

Key Words: chromosome, egl-13, egl-38, gene regulation, lin-39