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doi:10.1534/genetics.106.067595
A more recent version of this article appeared on February 1, 2007.
REGULAR RESEARCH PAPERS |
An Analysis of Univalent Segregation in Meiotic Mutants of Arabidopsis thaliana: A Possible Role for Synaptonemal Complex
Mónica Pradillo 1, Eva López 1, Concepción Romero 1, Eugenio Sánchez-Morán 2, Nieves Cuñado 1 and Juan L Santos 1*
1 Universidad Complutense
2 University of Birmingham
* To whom correspondence should be addressed. E-mail: jlsc53{at}bio.ucm.es.
Submitted on November 2, 2006
Revised on November 8, 2006
Accepted on 8 November 2006
During first meiotic prophase homologous chromosomes are normally kept together by both crossovers and synaptonemal complexes (SC). In most eukaryotes the SC disassembles at diplotene, leaving chromosomes joined by chiasmata. The correct co-orientation of bivalents at metaphase I and the reductional segregation at anaphase I are facilitated by chiasmata and sister chromatid cohesion. In the absence of meiotic reciprocal recombination, homologues are expected to segregate randomly at anaphase I. Here, we have analyzed the segregation of homologous chromosomes at anaphase I in four meiotic mutants of Arabidopsis thaliana, spo11-1-3, dsy1, mpa1 and asy1, which show a high frequency of univalents at diplotene. The segregation pattern of chromosomes 2, 4 and 5 was different in each mutant. Homologous univalents segregated randomly in spo11-1-3, whereas they did not in dsy1 and mpa1. An intermediate situation was observed in asy1. Also, we have found a parallelism between this behavior and the synaptic pattern displayed by each mutant. Thus, whereas spo11-1-3 and asy1 showed low amounts of SC stretches, dsy1 and mpa1 showed full synapsis. These findings suggest that in Arabidopsis there is a system, depending on the SC formation, that would facilitate regular disjunction of homologous univalents to opposite poles at anaphase I.
Key Words: Arabidopsis, chromosome segregation, meiotic mutants, synaptonemal complex
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