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doi:10.1534/genetics.106.067215
A more recent version of this article appeared on May 1, 2007.
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Adaptation of a quantitative trait to a moving optimum
Michael Kopp 1* and Joachim Hermisson 1
1 Ludwig-Maximilian University Munich
* To whom correspondence should be addressed. E-mail: kopp{at}zi.biologie.uni-muenchen.de.
Submitted on October 24, 2006
Revised on January 21, 2007
Accepted on 27 February 2007
We investigate adaptive evolution of a quantitative trait under stabilizing selection with a moving optimum. We characterize three regimes, depending on whether (1) the beneficial mutation rate, (2) the fixation time, or (3) the rate of environmental change is the limiting factor for adaptation. If the environment is rate-limiting, mutations with a small phenotypic effect are prefered over large mutations, in contrast to standard theory.
Key Words: adaptive walks, environmental change, fixation, major and minor loci, quantitative genetics
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