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doi:10.1534/genetics.106.066746
A more recent version of this article appeared on August 1, 2007.
REGULAR RESEARCH PAPERS |
Cytotype Regulation by Telomeric P elements in Drosophila melanogaster: Evidence for Involvement of an RNA Interference Gene
Michael J Simmons 1*, Don-Felix Ryzek 1, Cecile Lamour 1, Joseph W Goodman 1, Nicole E Kummer 1 and Peter J Merriman 1
1 University of Minnesota, Twin Cities
* To whom correspondence should be addressed. E-mail: simmo004{at}umn.edu.
Submitted on October 11, 2006
Revised on February 13, 2007
Accepted on 23 April 2007
P elements inserted at the left telomere of the X chromosome evoke the P cytotype, a maternally inherited condition that regulates the P-element family in the Drosophila germ line. This regulation is completely disrupted in stocks heterozygous for mutations in aubergine, a gene whose protein product is involved in RNA interference. However, cytotype is not disrupted in stocks heterozygous for mutations in two other RNAi genes, piwi and homeless (spindle-E), or in a stock heterozygous for a mutation in the chromatin protein gene Enhancer of zeste. aubergine mutations exert their effects in the female germ line, where the P cytotype is normally established and through which it is maintained. These effects are transmitted maternally to offspring of both sexes independently of the mutations themselves. Lines derived from mutant aubergine stocks reestablish the P cytotype quickly, unlike lines derived from stocks heterozygous for a mutation in Suppressor of variegation 205, the gene that encodes the telomere-capping protein HP1. Cytotype regulation by telomeric P elements may be tied to a system that uses RNAi to regulate the activities of telomeric retrotransposons in Drosophila.
Key Words: P elements, RNA interference, cytotype, hybrid dysgenesis, telomere
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