- THIS ARTICLE
- Full Text (Rapid PDF)
- Data Supplement
-
All Versions of this Article:
genetics.106.066720v1
175/3/1407 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Zhao, Z.
- Articles by Baillie, D. L.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Zhao, Z.
- Articles by Baillie, D. L.
doi:10.1534/genetics.106.066720
A more recent version of this article appeared on March 1, 2007.
REGULAR RESEARCH PAPERS |
Comparative Genomics and Adaptive Selection of the ATP-Binding Cassette (ABC) Transporter Family in Caenorhabditis Species
Zhongying Zhao 1*, James H. Thomas 1, Nansheng Chen 2, Jonathan A. Sheps 3 and David L. Baillie 2
1 University of Washington
2 Simon Fraser University
3 British Columbia Cancer Research Center
* To whom correspondence should be addressed. E-mail: zhao{at}gs.washington.edu.
Submitted on October 11, 2006
Revised on November 29, 2006
Accepted on 24 December 2006
ABC transporters constitute one of the largest gene families in all species. They are mostly involved in transport of substrates across membranes. We have previously demonstrated that the C. elegans ABC family shows poor one-to-one gene orthology with other distant model organisms. In order to address the evolution dynamics of this gene family among closely related species, we carried out a comparative analysis of ABC family among the three nematode species, C. elegans, briggsae and remanei. In contrast to the previous observations, the majority of ABC genes in the three species were found in orthologous trios, including many tandemly duplicated ABC genes, indicating the gene duplication took place before speciation. Species-specific expansions of ABC members are rare and mostly observed in subfamilies A and B. C. briggsae and C. remanei orthologous ABC genes tend to cluster on trees, with those of C. elegans as an outgroup, consistent with their proposed species phylogeny. Comparison of intron/exon structures of the highly conserved ABCE subfamily members also indicates a closer relationship between C. briggsae and C. remanei than between either of these species and C. elegans. A comparison between insect and mammalian species indicates lineage-specific duplications or deletions of ABC genes, while the family size remains relatively constant. Sites undergoing positive selection were identified within subfamily D, which are implicated in very long chain fatty acid transport. The evolution of these sites might be driven by the changes in food source with time.
Key Words: ABC, adaptive selection, evolution, gene family
This article has been cited by other articles:
 |
|
 |
|
  J. H. Thomas Genome evolution in Caenorhabditis Brief Funct Genomic Proteomic, June 23, 2008; (2008) eln022v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Currie, B. King, A. L. Lawrenson, L. K. Schroeder, A. M. Kershner, and G. J. Hermann Role of the Caenorhabditis elegans Multidrug Resistance Gene, mrp-4, in Gut Granule Differentiation Genetics, November 1, 2007; 177(3): 1569 - 1582. [Abstract] [Full Text] [PDF]
|
|