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doi:10.1534/genetics.106.065771
A more recent version of this article appeared on March 1, 2007.
REGULAR RESEARCH PAPERS |
Natural Genetic Variation in Cuticular Hydrocarbon Expression in Male and Female D. melanogaster
Brad R Foley 1*, Stephen F Chenoweth 2, Sergey V Nuzhdin 1 and Mark W Blows 2
1 University of California at Davis
2 University of Queensland
* To whom correspondence should be addressed. E-mail: brfoley{at}ucdavis.edu.
Submitted on September 12, 2006
Revised on November 7, 2006
Accepted on 19 December 2006
Cuticular Hydrocarbons (CHCs) act as contact pheromones in Drosophila melanogaster and are an important component of several ecological traits. Segregating genetic variation in the expression of CHCs at the population level in D. melanogaster is likely to be important for mate choice and climatic adaptation; however this variation has never been characterized. Using a panel of Recombinant Inbred lines (RILs) derived from a natural population we found significant between-line variation for nearly all CHCs in both sexes. We identified 25 QTL in females and 15 QTL in males that pleiotropically influence CHC expression. There was no evidence of colocalisation of QTL for homologous traits across the sexes, indicating that sexual dimorphism and low intersex genetic correlations between homologous CHCs are a consequence of largely independent genetic control. This is consistent with a pattern of divergent sexual and natural selection between the sexes.
Key Words: Cuticular Hydrocarbons, Drosophila melanogaster, Quantitative Trait Loci, Recombinant Inbred Lines, Sexual Dimorphism
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