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doi:10.1534/genetics.106.065201
A more recent version of this article appeared on January 1, 2007.
REGULAR RESEARCH PAPERS |
Mutations leading to loss of sporulation ability in Bacillus subtilis are sufficiently frequent to favor genetic canalization
Joanna Masel 1* and Heather Maughan 1
1 University of Arizona
* To whom correspondence should be addressed. E-mail: masel{at}u.arizona.edu.
Submitted on August 23, 2006
Revised on October 16, 2006
Accepted on 16 October 2006
We measured the rate of mutations impairing sporulation ability in Bacillus subtilis as 0.003 in a mutator population, following 6000 generations of strong selection for sporulation that have previously been described. This means that the product of the population size and the functional mutation rate is around 105, well within the parameter range for which genetic canalization of sporulation ability is expected.
Key Words: cryptic genetic variation, experimental evolution, mutation rate, neutral networks, robustness
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  H. Maughan, J. Masel, C. W. Birky Jr., and W. L. Nicholson The Roles of Mutation Accumulation and Selection in Loss of Sporulation in Experimental Populations of Bacillus subtilis Genetics, October 1, 2007; 177(2): 937 - 948. [Abstract] [Full Text] [PDF]
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