Genetics. Published Articles Ahead of Print: May 4, 2007, Copyright © 2007
doi:10.1534/genetics.106.064980


A more recent version of this article appeared on August 1, 2007.

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Bayesian Multiple Quantitative Trait Loci Mapping for Complex Traits Using Markers of the Entire Genome

Hanwen Huang 1, Chevonne D. Eversley 1, David W. Threadgill 1 and Fei Zou 1*

1 University of North Carolina, Chapel Hill

* To whom correspondence should be addressed. E-mail: fzou{at}bios.unc.edu.

Submitted on August 17, 2006
Revised on October 30, 2006
Accepted on 28 April 2007


Abstract

A Bayesian methodology has been developed for multiple Quantitative Trait Loci (QTL) mapping of complex binary traits that follow liability threshold models. Unlike most QTL mapping methods where only one or a few markers are used at a time, the proposed method utilizes all markers across the genome simultaneously. The out-performance of our Bayesian method over the traditional single-marker analysis and interval mapping has been illustrated via simulations and real data analysis to identify candidate loci associated with colorectal cancer.

Key Words: Binary Trait, MCMC, QTL Mapping, Threshold Model




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