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doi:10.1534/genetics.106.064311
A more recent version of this article appeared on January 1, 2007.
REGULAR RESEARCH PAPERS |
Quantitative Trait Loci by Maternal Cytoplasmic Environment Interaction for Development Rate in Oncorhynchus mykiss
Krista M. Nichols 1*, Karl W Broman 2, Kyle Sundin 3, Jennifer Young 3, Paul Wheeler 3 and Gary H. Thorgaard 3
1 Purdue University
2 Johns Hopkins University
3 Washington State University
* To whom correspondence should be addressed. E-mail: kmnichol{at}purdue.edu.
Submitted on August 2, 2006
Revised on September 5, 2006
Accepted on 2 October 2006
Effects of maternal cytoplasmic environment (MCE) on development rate in rainbow trout were evaluated within a quantitative trait loci (QTL) analysis framework. Previous research had identified QTL for development rate in doubled haploid (DH) progeny produced from a cross between the Oregon State University (OSU) and the Swanson (SW) River rainbow trout clonal lines. In this study, progeny for QTL mapping were produced from a cross between the OSU and Clearwater (CW) River clonal lines. Doubled haploids were produced from the OSUxCW F1 by androgenesis using eggs from different females (or MCEs); with androgenesis, the maternal nuclear genome was destroyed by irradiation and diploidy restored by blocking the first embryonic cleavage by heat shock. All embryos were incubated at the same temperature and development rate quantified as time to hatch. Using a linkage map constructed primarily with AFLP markers, QTL mapping was performed including MCE covariates and QTLxMCE effects in models for testing. The major QTL for development rate in the OSUxSW cross overlaps with the major QTL found in this OSUxCW cross; effects at this locus were the same across MCEs. MCE and QTLxMCE effects both contribute to variability in development rate, but QTLxMCE were minor and only detected at small-effect QTL.
Key Words: QTL, androgenesis, development rate, maternal effects, rainbow trout
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