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doi:10.1534/genetics.106.063453
A more recent version of this article appeared on December 1, 2006.
REGULAR RESEARCH PAPERS |
EMB-4: A predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans
Iskra Katic 1 and Iva Greenwald 1*
1 Columbia University
* To whom correspondence should be addressed. E-mail: greenwald{at}cancercenter.columbia.edu.
Submitted on July 14, 2006
Revised on August 5, 2006
Accepted on 5 August 2006
The sel-6 gene was previously identified in a screen for suppressors of the egg-laying defect associated with hypermorphic alleles of lin-12 (TAX et al. 1997). Here, we show that sel-6 and two other previously-defined genes, mal-2 and emb-4, are the same gene, now called "emb-4". We perform a genetic and molecular characterization of emb-4, and show that it functions cell-autonomously as a positive regulator of lin-12 activity. Viable alleles identified as suppressors of lin-12 are partial loss-of-function mutations, whereas the null phenotype encompasses a range of lethal terminal phenotypes that are not apparently related to loss of lin-12/Notch signaling. emb-4 encodes a large nuclearly localized protein containing a predicted ATPase domain, and has apparent orthologs in fission yeast, plants and animals.
Key Words: ATPase, Notch
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