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Genetics. Published Articles Ahead of Print: October 22, 2006, Copyright © 2006
doi:10.1534/genetics.106.063057

A more recent version of this article appeared on December 1, 2006.
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Unexpected high polymorphism at FABP4 gene unveils a complex history for pig populations

Ana Ojeda 1, Julio Rozas 2, Josep M Folch 1 and Miguel Perez-Enciso 1*

1 Universitat Autonoma de Barcelona
2 Universitat de Barcelona

* To whom correspondence should be addressed. E-mail: miguel.perez{at}uab.es.

Submitted on July 7, 2006
Revised on September 10, 2006
Accepted on 9 October 2006


  Abstract
Fatty acid bing protein 4 (FABP4) plays a key role in fat regulation in mammals and is a strong positional candidate gene for the FAT1 quantitative trait locus located on porcine chromosome 4. DNA resequencing of the FABP4 gene region in 23 pigs from ten breeds and wild boar revealed 134 variants in 6.4 kb, representing a silent nucleotide diversity of {pi}s, 0.01, much higher than reported so far in animal domestic species. Moreover, this diversity was highly structured. Also strikingly, the FABP4 phylogenetic tree did not show any geographical or breed origin clustering, with distant breeds sharing similar haplotypes and some of the most heterozygous samples pertaining to highly inbred animals like Iberian Guadyerbas (inbreeding coefficient ~ 0.3) or British Tamworth. In contrast, the cytochrome b (mtDNA) phylogenetic tree was coherent with geographical origin. The estimated age of the most recent common ancestor for the most divergent Iberian or Tamworth haplotypes was much older than domestication. An additional panel of a hundred pigs from eight different breeds and wild boar from Spain, Tunisia, Sardinia and Japan was genotyped for seven selected single nucleotide polymorphisms and shows that high variability at porcine's FABP4 is the rule rather than the exception. Pig populations, even highly inbred, can maintain high levels of variability for surprisingly long periods of time.

Key Words: FABP4, Pig, Selection Footprint




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A. Ojeda, L.-S. Huang, J. Ren, A. Angiolillo, I.-C. Cho, H. Soto, C. Lemus-Flores, S. M. Makuza, J. M. Folch, and M. Perez-Enciso
Selection in the Making: A Worldwide Survey of Haplotypic Diversity Around a Causative Mutation in Porcine IGF2
Genetics, March 1, 2008; 178(3): 1639 - 1652.
[Abstract] [Full Text] [PDF]


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